David A. Wilcox, PhD

Title
Investigator, Children's Research Institute.

Division
Hematology, Oncology and Transplant

Research center/program
Bleeding disorders research

Research interests
Bleeding and blood disorders

Study interests
Gene therapy, hematopoietic stem cells, inherited bleeding disorders, integrins, platelets.

Education
Bachelor's degree, Chemistry, University of Wisconsin-Madison, 1987; Doctorate, Cellular Biology and Anatomy, Medical College of Wisconsin, Milwaukee, 1994.

National advisory committees/activities
Scientific reviewer, Thrombosis and Haemostasis, Journal of Thrombosis and Haemostasis, Blood and Biology of Blood and Marrow Transplantation; Ad hoc reviewer, National Institutes for Health Study Section for Hemostasis and Thrombosis.

Professional/honorary societies
American Heart Association, Scientific Council member; American Society of Gene Therapy, American Society of Hematology, International Society of Thrombosis and Haemostasis.

Invited presentations
Gordon Research Conference on Hemostasis, Plymouth, N.H., 2000, Use of aIIb Promoter in Retroviral Constructs; BMS Seminar/Goodwin Lecturer, Auburn University, Alabama, 2002, Targeting Gene Therapy for Inherited Hematological Disorders and The Molecular Basis for Gene Therapy Using Hematopoietic Stem Cells; 45th Annual Meeting of the American Society of Hematology, San Diego, 2003, EM Localization and Agonist-induced Release of Human FVIII from Megakaryocytes Transduced with a FVIII Transgene; Telethon Institute of Genetics and Medicine, Naples, Italy, 2004, Gene Therapy for Inherited Platelet Disorders; European Science Foundation Exploratory Workshop: Applying New Technologies to the Study of Inherited Disorders of Megakaryocytes and Platelets, Naples, Italy, 2004, Gene Therapy for Inherited Platelet Disorders; Gordon Research Conference on Cell Biology of Megakaryocytes and Platelets, Santa Barbara, Calif., invited discussion leader.

Representative publications

• Wilcox DA, White II GC. Gene Therapy for Platelet Disorders. Platelets. Michelson AD (ed.), Academic Press, San Diego. 2002; 61:927-37.
• Wilcox DA, White II GC. Gene Therapy for Platelet Disorders: Studies with Glanzmann's Thrombasthenia. Journal of Thrombosis and Haemostasis. 2003; 1:2300-2311.
• Wilcox DA, Shi Q, Nurden P, Haberichter SL, Rosenberg JB, Johnson BD, Nurden AT, White II GC, Montgomery RR. Induction of Megakaryocytes to Synthesize and Store a Releasable Pool of Human Factor VIII, Focus Article. Journal of Thrombosis and Haemostasis. 2003; 1:2477-89.
• Niemeyer GP, Boudreaux MK, Goodman-Martin SA, Monroe CM, Wilcox DA, Lothrop Jr CD. Correction of a Large Animal Model of Type I Glanzmann's Thrombasthenia by Nonmyeloablative Marrow Transplantation. Experimental Hematology. 2003; 31:1357-62.
• Shi Q, Wilcox DA, Morateck PA, Fahs SA, Kenny D, Montgomery RR. Targeting Platelet GPIbá Transgene Expression to Human Megakaryocytes and Forming a Complete Complex with Endogenous GPIbâ and GPIX. Journal of Thrombosis and Haemostasis. 2004; 2:1989-1997.
• Fang J, Hodivala-Dilke KM, Johnson BD, Hynes RO, White II GC, Wilcox DA. Therapeutic Expression of the Platelet-specific Integrin, aIIbb3, in a Murine Model for Glanzmann Thrombasthenia. 2004.

Grants

• Therapeutic Expression of a Platelet-specific Integrin, principal investigator (50 percent effort), National Heart Lung and Blood Institute, RO1 HL 068138-03, 2002-2006.
• Molecular and Cellular Mechanisms in Transfusion Medicine, collaborator (10 percent effort), NHLBI, HL 44612-15, 2000-2005.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 456-4998
Fax: (414) 456-6543
E-mail: dwilcox@mcw.edu