
David A. Wilcox, PhD
Title Investigator, Children's Research Institute.
Division Hematology, Oncology and Transplant
Research center/program Bleeding disorders research
Research interests Bleeding and blood disorders
Study interests Gene therapy, hematopoietic stem cells, inherited bleeding disorders, integrins, platelets.
Education Bachelor's degree, Chemistry, University of Wisconsin-Madison, 1987; Doctorate, Cellular Biology and Anatomy, Medical College of Wisconsin, Milwaukee, 1994.
National advisory committees/activities Scientific reviewer, Thrombosis and Haemostasis, Journal of Thrombosis and Haemostasis, Blood and Biology of Blood and Marrow Transplantation; Ad hoc reviewer, National Institutes for Health Study Section for Hemostasis and Thrombosis.
Professional/honorary societies American Heart Association, Scientific Council member; American Society of Gene Therapy, American Society of Hematology, International Society of Thrombosis and Haemostasis.
Invited presentations Gordon Research Conference on Hemostasis, Plymouth, N.H., 2000, Use of aIIb Promoter in Retroviral Constructs; BMS Seminar/Goodwin Lecturer, Auburn University, Alabama, 2002, Targeting Gene Therapy for Inherited Hematological Disorders and The Molecular Basis for Gene Therapy Using Hematopoietic Stem Cells; 45th Annual Meeting of the American Society of Hematology, San Diego, 2003, EM Localization and Agonist-induced Release of Human FVIII from Megakaryocytes Transduced with a FVIII Transgene; Telethon Institute of Genetics and Medicine, Naples, Italy, 2004, Gene Therapy for Inherited Platelet Disorders; European Science Foundation Exploratory Workshop: Applying New Technologies to the Study of Inherited Disorders of Megakaryocytes and Platelets, Naples, Italy, 2004, Gene Therapy for Inherited Platelet Disorders; Gordon Research Conference on Cell Biology of Megakaryocytes and Platelets, Santa Barbara, Calif., invited discussion leader.
Representative publications
- Wilcox DA, White II GC. Gene Therapy for Platelet Disorders. Platelets. Michelson AD (ed.), Academic Press, San Diego. 2002; 61:927-37.
- Wilcox DA, White II GC. Gene Therapy for Platelet Disorders: Studies with Glanzmann's Thrombasthenia. Journal of Thrombosis and Haemostasis. 2003; 1:2300-2311.
- Wilcox DA, Shi Q, Nurden P, Haberichter SL, Rosenberg JB, Johnson BD, Nurden AT, White II GC, Montgomery RR. Induction of Megakaryocytes to Synthesize and Store a Releasable Pool of Human Factor VIII, Focus Article. Journal of Thrombosis and Haemostasis. 2003; 1:2477-89.
- Niemeyer GP, Boudreaux MK, Goodman-Martin SA, Monroe CM, Wilcox DA, Lothrop Jr CD. Correction of a Large Animal Model of Type I Glanzmann's Thrombasthenia by Nonmyeloablative Marrow Transplantation. Experimental Hematology. 2003; 31:1357-62.
- Shi Q, Wilcox DA, Morateck PA, Fahs SA, Kenny D, Montgomery RR. Targeting Platelet GPIbá Transgene Expression to Human Megakaryocytes and Forming a Complete Complex with Endogenous GPIbâ and GPIX. Journal of Thrombosis and Haemostasis. 2004; 2:1989-1997.
- Fang J, Hodivala-Dilke KM, Johnson BD, Hynes RO, White II GC, Wilcox DA. Therapeutic Expression of the Platelet-specific Integrin, aIIbb3, in a Murine Model for Glanzmann Thrombasthenia. 2004.
Grants
- Therapeutic Expression of a Platelet-specific Integrin, principal investigator (50 percent effort), National Heart Lung and Blood Institute, RO1 HL 068138-03, 2002-2006.
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Molecular and Cellular Mechanisms in Transfusion Medicine, collaborator (10 percent effort), NHLBI, HL 44612-15, 2000-2005.
Contact Children's Research Institute 8701 Watertown Plank Road Wauwatosa, WI 53226 Phone: (414) 456-4998 Fax: (414) 456-6543 E-mail: dwilcox@mcw.edu

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