David A. Wilcox, PhD

Hematology/Oncology

Education: Bachelor's degree, Chemistry, University of Wisconsin, 1987; PhD, Cellular Biology & Anatomy, Medical College of Wisconsin, Milwaukee, 1994.

National advisory committees and/or activities: Scientific reviewer, Thrombosis and Haemostasis, Journal of Thrombosis and Haemostasis, Blood and Biology of Blood and Marrow Transplantation; Ad hoc reviewer, National Institutes for Health Study Section for Hemostasis and Thrombosis.

Professional and honorary societies: American Heart Association, Scientific Council member; American Society of Gene Therapy, American Society of Hematology, International Society of Thrombosis and Haemostasis.

Invited presentations: Gordon Research Conference on Hemostasis, Plymouth, N.H., 2000, Use of aIIb Promoter in Retroviral Constructs; BMS Seminar/Goodwin Lecturer, Auburn University, Alabama, 2002, Targeting Gene Therapy for Inherited Hematological Disorders and The Molecular Basis for Gene Therapy Using Hematopoietic Stem Cells; 45th Annual Meeting of the American Society of Hematology, San Diego, 2003, EM localization and agonist-induced release of human FVIII from megakaryocytes transduced with a FVIII transgene;  Telethon Institute of Genetics and Medicine, Naples, Italy, 2004, Gene therapy for Inherited Platelet Disorders; European Science Foundation Exploratory Workshop: Applying new technologies to the study of inherited disorders of megakaryocytes and platelets, Naples, Italy, 2004, Gene therapy for Inherited Platelet Disorders; Gordon Research Conference on Cell Biology of Megakaryocytes and Platelets, Santa Barbara, Calif., invited discussion leader.

Research interests: Gene therapy, hematopoietic stem cells, inherited bleeding disorders, platelets and integrins.

Representative publications:

• Wilcox DA, White II GC. Gene Therapy for Platelet Disorders, Platelets. A.D. Michelson (ed.), Academic Press, San Diego, Chapter 61: 927-37, 2002.
• Wilcox DA, White II GC. Gene Therapy for Platelet Disorders: Studies with Glanzmann's Thrombasthenia. Journal of Thrombosis and Haemostasis. 1: 2300-2311, 2003.
• Wilcox DA, Shi Q, Nurden P, Haberichter SL, Rosenberg JB, Johnson BD, Nurden AT, White II GC, Montgomery RR. Induction of Megakaryocytes to Synthesize and Store a Releasable Pool of Human Factor VIII, Focus Article, Journal of Thrombosis and Haemostasis. 1: 2477-89, 2003.
• Niemeyer GP, Boudreaux MK, Goodman-Martin SA, Monroe CM, Wilcox DA, Lothrop Jr CD. Correction of a Large Animal Model of Type I Glanzmann's Thrombasthenia by Nonmyeloablative Marrow Transplantation, Experimental Hematology. 31:1357-62, 2003.
• Shi Q, Wilcox DA, Morateck PA, Fahs SA, Kenny D, Montgomery RR. Targeting Platelet GPIbá Transgene Expression to Human Megakaryocytes and Forming a Complete Complex with Endogenous GPIbâ and GPIX, Journal of Thrombosis and Haemostasis. 2: 1989-1997, 2004.
• Fang J, Hodivala-Dilke KM, Johnson BD, Hynes RO, White II GC, Wilcox DA. Therapeutic Expression of the Platelet-specific Integrin, aIIbb3, in a Murine Model for Glanzmann Thrombasthenia, submitted, 2004.

Current grants:

• Therapeutic Expression of a Platelet-Specific Integrin, principal investigator (50 percent effort), (NHLBI) RO1 HL 068138-03, 2002-2006.
• Molecular and Cellular Mechanisms in Transfusion Medicine, collaborator (10 percent effort), (NHLBI) HL 44612-15, 2000-2005.

Contact information: 8701 Watertown Plank Road, Milwaukee, WI 53226. Phone: (414) 456-4998. Fax: (414) 456-6543. E-mail: dwilcox@mcw.edu.