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Ellis D. Avner, MD

Titles
Director, Children's Research Institute; associate dean Research; professor, Pediatrics and Physiology. Medical College of Wisconsin; associate director, S.E. Wisconsin Clinical Translational Science Award/Institute.

Division
Nephrology

Research center/program
Director, Research Center of Excellence in Pediatric Nephrology.

Research interests
Behavioral health, Cancer, cell and developmental biology, environmental health, genetic diseases/genomics, kidney diseases/urological disorders, solid organ transplantation.

Study interests
Polycystic kidney disease, kidney disease, kidney development.

Education
Medical degree, University of Pennsylvania School of Medicine, Philadelphia, 1975; residency, The Children's Hospital, Boston, 1975-1978; fellowship, The Children's Hospital, Boston, 1978-1980.

Certifications
Pediatrics 1980, Pediatric Nephrology 1982.

Honors
America's Top Doctors, Castle Connolly Medical Ltd., 2001-2002; Standing Committee, International Pediatric Association, 2001-2007; Councilor, International Pediatric Nephrology Association, 2001-2007; Million Dollar Professor, Case Western Reserve University 2001-2003; March of Dimes Distinguished Lecturer, New York Academy of Medicine, 2002; Junvenile Diabetes Foundation Award for Research Achievement, 2002; President, American Society of Pediatric Nephrology, 2002-2004; Rainbow Babies Corporation, Chair for Excellence in Pediatrics, 2004; President, Council of American Kidney Societies, 2003-2004; Honored Member, Lifetime Achievement Award, Strathmore's Who's Who, 2004 -; Howard Mermelstein Memorial Lecture, Children's Hospital of Pittsburgh, 2003; Award of Tenure, Medical College of Wisconsin, 2004; Executive Committee, International Pediatric Association, 2004-2007; Henry L. Barnett Award for Excellence in Clinical Care and Education in Pediatric Nephrology, American Academy of Pediatrics, 2008; Best Doctors in America (Castle-Connely) 2009, 2010.

Representative publications

Sweeney WE and Avner ED. Molecular and Cellular Pathophysiology of Autosomal Recessive Polycystic Kidney Disease. Cell Tissue Res. 2006; 326:671-685. PMID: 1676405.
Sweeney WE, Avner ED. Renal Cystic Disease: New Insights for the Clinician. Pediatr Clin North Am. 2006; 53:889-9089. PMID: 17027616.
Sweeney WE, von Bigier RO, Frost P. Avner ED. Src Inhibition Ameliorates Autosomal Recessive Polycystic Kidney Disease in the BPK Murine Model. Journal American Society Nephrology. 2008; 19:1331-1341. PMCID: PMC2440293
Park F, Sweeney WE, Guanggfu J, Akbulut T, Mueller B, Falck J, Birudaraju S, Roman R, Avner ED. Chronic Blockade of 20-HETE Synthesis Reduces Polycystic Kidney Disease in an Orthologous Rat Model of ARPKD. Amer J Physiol Renal. 2009; 296:575-582. PMCID: PMC2660198.
Akbulut T, Regner K, Roman R, Avner E, Falck J, Park R. 20-HETE Activates the Raf/MEK/ERK Pathway in Renal Epithelial Cells through EGFR- and c-Src-Dependent Mechanism. Amer J Physiol Renal. 2009; 297(3):F662-70. PMCID: PMC2739708.
Avner ED, Harmon W, Niaudet P, Yoshikawa N (eds): Pediatric Nephrology, 6th Edition in 2 volumes, Springer-Verlag, Heidelberg, 2009.
Sweeney WE, Avner ED. Diagnosis and Management of Childhood Polycystic Kidney Disease. Pediatric Nephrology. 2010 (In press). (EPub ahead of print) PMID 21046169.

Grants

National Institutes of Health, Integrative Biology of Childhood Kidney Disease: Research Center of Excellence in Pediatric Nephrology, principal investigator, Overall Center; principal investigator, Administrative Core; principal investigator, Project 1: Modulation of Disease Prevention in ARPKD 2007-2012.
OSI Pharmaceuticals, Tarceva as a Therapeutic Agent for ARPKD: Preclinical Studies, principal investigator, 2008-2011.
National Institutes of Health, ARRA 2009 Supplement: Integrative Biology of Childhood Kidney Disease, principal investigator, 2009- 2011.
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Diversity Research Supplement Award (M. Saleh, M.D.), principal investigator, 2010-2012.
Primrose Pharmaceuticals, Pre-clinical Studies of XL-647 in PKD, principal investigator, 2010-2012.
National Institutes of Health, Southeastern Wisconsin Clinical and Translational Science Award, co-principal investigator, 2010-2015.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 337-7702
Fax: (414) 337-7105
E-mail: eavner@mcw.edu