Ellis D. Avner, MD
Titles
Director, Children's Research Institute; professor, Pediatrics, associate dean, Research, Medical College of Wisconsin.
Division
Nephrology
Research center/program
Director, Children's Kidney Disease Research Program; director, Renal Center of Excellence in Pediatric Nephrology.
Research interests
Cell and developmental biology, childhood kidney disease
Study interests
Congenital renal anomalies, polycystic kidney disease, renal developmental biology.
See extended bio.
Education
Medical degree, University of Pennsylvania School of Medicine, Philadelphia, 1975; residency, The Children's Hospital, Boston, 1975-1978; fellowship, The Children's Hospital, Boston, 1978-1980.
Certifications
National Board of Examiners, 1976; American Board of Pediatrics, 1980; Sub-board of Pediatric Nephrology, 1982.
Representative publications
Sweeney WE, Kusner L, Carlin CR, Chang S, Futey L, Cotton CU, Avner ED. Phenotypic Analysis of Conditionally Immortalized Cells Isolated from the BPK Model of ARPKD. American Journal of Physiology. 2001; 281:C1695-1705.
Onuchic LF, Furu L, Nagasawa Y, Hou X, Eggerman T, Ren Z, Bergmann C, Sanderek J, Esquivel E, Zeltner R, Rudnic-Schoneborn S, Mrug M, Sweeney W, Avner ED, Zerres K, Guay-Woodford LM, Somio S, Germino GG. PKHD1, the Polycystic Kidney and Hepatic Disease 1 Gene (PKHD1) Encodes a Novel Large Protein Containing Multiple IPT Domains and PbH1 Repeats. American Journal of Human Genetics. 2002; 70:1305-1317.
Torres VE, Sweeney WE, Wang X, Qian Q, Harris PC, Frost P, Avner ED. EGF Receptor Tyrosine Kinase Inhibition Attenuates the Development of PKD in Han:SPRD Rats. Kidney International. 2003; 64:1573-1579.
Sweeney WE, Hamahira K, Sweeney J, Garcia-Gattell M, Frost P, Avner ED. Combination Treatment of PKD Utilizing Dual Inhibition of EGF-receptor Activity and Ligand Bioavailability. Kidney International. 2003; 64:1310-1319.
Dell KM, Nemo R, Sweeney WE, Avner ED. EGF-related Growth Factors in the Pathogenesis of Murine ARPKD. Kidney International. 2004; 65:2018-2029.
Sweeney B, Avner ED. Molecular and Cellular Pathophysiology of ARPKD. Cell and Tissue Research. 2006; 326(3):671-685.
Sweeney WE, von Vigier RO, Avner ED. Src Inhibition Ameliorates Autosomal Recessive Polycystic Kidney Disease in the BPK Murine Model. Journal of the American Society of Nephrology. 2008; 19:1331-1341.
Park F, Sweeney WE, Jia G, Roman RJ, Avner ED. 20-HETE Mediates Proliferation of Renal Epithelial Cells in Polycystic Kidney Disease. Journal of the American Society of Nephrology. 2008; 19:1929-1940.
Park F, Sweeney WE, Guanggfu J, Akbulut T, Mueller B, Falck J, Birudaraju S, Roman R, Avner ED. Chronic Blackade of 20-HETE Synthesis Reduces Polycystic Kidney Disease in an Orthologous Rat Model of ARPKD. American Journal of Physiology-Renal Physiology. 2009; 296:575-582.
Akbulut T, Regner K, Roman R, Avner E, Falck J, Park F. 20-HETE Activates the Raf/MEK/ERK Pathway in Renal Epithelial Cells through EGFR- and c-Src-Dependent Mechanism. American Journal of Physiology-Renal Physiology. 2009 (In press).
Avner ED, Harmon W, Niaudet P, Yoshikawa N (eds). Pediatric Nephrology, Sixth Edition. Springer-Vertag. 2009.
Grants
Integrative Biology of Children's Kidney Disease: Research Center of Excellence in Pediatric Nephrology, principal investigator, National Intitutes of Health, 1-P50-DK079306, administrative core and project two: Arachidonic Acid Metabolites in ARPKD, 2007-2012.
Pre-clinical Studies of XL-784 in Polycystic Kidney Disease, principal investigator, Exelixis Pharmaceuticals, 2007-2009.
Pre-clinical Studies of Pan Erb-B inhibition in Polycystic Kidney Disease, principal investigator, GlaxoSmithKline Pharmaceuticals, 2008-2010.
Pre-clinical Studies of Nimotuzumab in Polycystic Kidney Disease, principal investigator, YM BioSciences, Calesca, 2008-2010.
Tarceva as a Therapeutic Agent for ARPKD: Preclinical Studies, principal investigator, OSI Pharmaceuticals, 2008-2010.
American Recovery and Reinvestment Act 2009 Supplement: Integrative Biology of Childhood Kidney Disease, principal investigator, National Institutes of Health (3 P50 DKO79306-03S1), 2009-2011.
Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 337-7702
Fax: (414) 337-7105
E-mail: eavner@mcw.edu
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