Ellis D. Avner, MD

Ellis Avner, MD

Titles
Director, Children's Research Institute; associate dean Research; professor, Pediatrics and Physiology. Medical College of Wisconsin; associate director, S.E. Wisconsin Clinical Translational Science Award/Institute.

Division
Nephrology

Research center/program
Director, Research Center of Excellence in Pediatric Nephrology.

Research interests
Behavioral health, Cancer, cell and developmental biology, environmental health, genetic diseases/genomics, kidney diseases/urological disorders, solid organ transplantation.

Study interests
Polycystic kidney disease, kidney disease, kidney development.

Education
Medical degree, University of Pennsylvania School of Medicine, Philadelphia, 1975; residency, The Children's Hospital, Boston, 1975-1978; fellowship, The Children's Hospital, Boston, 1978-1980.

Certifications
Pediatrics 1980, Pediatric Nephrology 1982.

Honors
America's Top Doctors, Castle Connolly Medical Ltd., 2001-2002; Standing Committee, International Pediatric Association, 2001-2007; Councilor, International Pediatric Nephrology Association, 2001-2007; Million Dollar Professor, Case Western Reserve University 2001-2003; March of Dimes Distinguished Lecturer, New York Academy of Medicine, 2002; Junvenile Diabetes Foundation Award for Research Achievement, 2002; President, American Society of Pediatric Nephrology, 2002-2004; Rainbow Babies Corporation, Chair for Excellence in Pediatrics, 2004; President, Council of American Kidney Societies, 2003-2004; Honored Member, Lifetime Achievement Award, Strathmore's Who's Who, 2004 -; Howard Mermelstein Memorial Lecture, Children's Hospital of Pittsburgh, 2003; Award of Tenure, Medical College of Wisconsin, 2004; Executive Committee, International Pediatric Association, 2004-2007; Henry L. Barnett Award for Excellence in Clinical Care and Education in Pediatric Nephrology, American Academy of Pediatrics, 2008; Best Doctors in America (Castle-Connely) 2009, 2010.

Representative publications

  • Sweeney WE and Avner ED. Molecular and Cellular Pathophysiology of Autosomal Recessive Polycystic Kidney Disease. Cell Tissue Res. 2006; 326:671-685. PMID: 1676405.
  • Sweeney WE, Avner ED. Renal Cystic Disease: New Insights for the Clinician. Pediatr Clin North Am. 2006; 53:889-9089. PMID: 17027616.
  • Sweeney WE, von Bigier RO, Frost P. Avner ED. Src Inhibition Ameliorates Autosomal Recessive Polycystic Kidney Disease in the BPK Murine Model. Journal American Society Nephrology. 2008; 19:1331-1341. PMCID: PMC2440293
  • Park F, Sweeney WE, Guanggfu J, Akbulut T, Mueller B, Falck J, Birudaraju S, Roman R, Avner ED. Chronic Blockade of 20-HETE Synthesis Reduces Polycystic Kidney Disease in an Orthologous Rat Model of ARPKD. Amer J Physiol Renal. 2009; 296:575-582. PMCID: PMC2660198.
  • Akbulut T, Regner K, Roman R, Avner E, Falck J, Park R. 20-HETE Activates the Raf/MEK/ERK Pathway in Renal Epithelial Cells through EGFR- and c-Src-Dependent Mechanism. Amer J Physiol Renal. 2009; 297(3):F662-70. PMCID: PMC2739708.
  • Avner ED, Harmon W, Niaudet P, Yoshikawa N (eds): Pediatric Nephrology, 6th Edition in 2 volumes, Springer-Verlag, Heidelberg, 2009.
  • Sweeney WE, Avner ED. Diagnosis and Management of Childhood Polycystic Kidney Disease. Pediatric Nephrology. 2010 (In press). (EPub ahead of print) PMID 21046169.

Grants

  • National Institutes of Health, Integrative Biology of Childhood Kidney Disease: Research Center of Excellence in Pediatric Nephrology, principal investigator, Overall Center; principal investigator, Administrative Core; principal investigator, Project 1: Modulation of Disease Prevention in ARPKD 2007-2012.
  • OSI Pharmaceuticals, Tarceva as a Therapeutic Agent for ARPKD: Preclinical Studies, principal investigator, 2008-2011.
  • National Institutes of Health, ARRA 2009 Supplement: Integrative Biology of Childhood Kidney Disease, principal investigator, 2009- 2011.
  • National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Diversity Research Supplement Award (M. Saleh, M.D.), principal investigator, 2010-2012.
  • Primrose Pharmaceuticals, Pre-clinical Studies of XL-647 in PKD, principal investigator, 2010-2012.
  • National Institutes of Health, Southeastern Wisconsin Clinical and Translational Science Award, co-principal investigator, 2010-2015.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 337-7702
Fax: (414) 337-7105
E-mail: eavner@mcw.edu

Investigator in areas of: