Education
Medical degree, University of California, Irvine, 1991; doctorate, University of California, Irvine, 1991; residency, St. Louis Children's Hospital, 1993, fellowship, Washington University School of Medicine and St. Louis Children's Hospital, 1996.

Certifications
Pediatrics, Pediatric Rheumatology.

Honors
Summer fellowship, California Foundation for Biochemical Research, 1982; Earl C. Anthony Dissertation Fellowship, 1989; MRES Medical Scientist Student Scholarship, 1990; Vincent P. Carroll Jr. Memorial Research Award for Outstanding Research, 1992; Scholar of the Center for Child Health Research at Washington University, 1997; Basil O'Connor Research Award, March of Dimes, 1998; D.B. and Marjorie Reinhart Chair in Rheumatology, 2002; Elected member, Society for Pediatric Research, 2003; Outstanding Health Professional Award-Arthritis Foundation, Wisconsin Chapter, 2004.

Representative publications

• Haribhai D, Lin W, Relland LM, Truong N,*Chatila TA and Williams CB. Regulatory T Cells Dynamically Control the Primary Immune Response to Foreign Antigen. Journal of Immunology. 2007; 178:2961-2972. *Corresponding authors
• Lin W, Haribhai D, Relland LM, Truong N, Carlson MR, *Williams CB, and *Chatila TA. Regulatory T Cell Development in the Absence of a Functional Foxp3 Protein. Nature Immunology. 2007; 8:359-368. *Corresponding authors.
• Schulteis RD, Chu H, Dai X, Chen Y, Edwards B, Haribhai D, Williams CB, Malarkannan S, Hessner MJ, Glisic-Milosavljevic S, Jana S, Kerchen EJ, Ghosh S, Wang D, Kwitek AE, Lernmark A, Gorski J, and Weiler H. Impaired Survival of Peripheral T Cells, Disrupted NK/NKT Cell Development, and Liver Failure in Mice Lacking gimap5. Blood. 2008; 112:4905-4914.
• Relland LM, Mishra MK, Haribhai D, Edwards B, Ziegelbauer J, and Williams CB. Affinity-based Selection of Regulatory T Cells Occurs Independent of Agonist-mediated Induction of Foxp3 Expression. Journal of Immunology. 2009; 182:1341-1350.
• Haribhai D, Lin W, Edwards B, Ziegelbauer J, Salzman NH, *Charila TA, and Williams CB. A Central Role for Induced Regulatory T Cells in Tolerance Induction in Experimental Colitis. Journal of Immunology.  2009; 182:3461-3468. *Corresponding authors.
• Jana S, Jailwala P, Ehlenbach S, Haribhai D, Waukau J, Glisic-Milosavljevic S, Grossman WJ, Verbsky JW, Wen R, Wang D, Williams CB and Ghosh S. The Role of Smad3 and NFkB in the Regulation of Foxp3 Expression in Effector Cells. Eur. Journal of Immunology. 2009; 39:1-13.
• Salzman NH, Hung K, Haribhai D, Chu H, Karlsson-Sjoberg, Amir E, Teggatz P, Barman M, Hayward J, Stoel M, Sodergren E, Bevins CL, Williams CB, George M. Weinstock, and Nicholas S. Bos. Enteric Defensins are Essential Regulators of Intestinal Microbial Ecology. Nature Immunology. 2009 (in press).

  Grants

• Immune Function and Biodefense in Children, Elderly and Immunocompromised Populations. The major goals of this contract are to examine the generation of T cell memory to influenza in special populations.  Role: Subcontract principal Investigator (2.4 calendar months).  National Institutes of Health, National Institute of Allergy and Infectious Diseases.
• Advancing a Healthier Wisconsin - Research for a Healthier Tomorrow Initiative, Medical College of Wisconsin. The Role of Induced Regulatory T Cells in Dominant Immunologic Tolerance, principal investigator (1.2 calendar months).
• Regulatory T Cells Selection and Specificity. The goals of this proposal are to determine the mechanisms of T_reg cell lineage specification in the thymus and to establish the contributions of T_reg cells to tolerance in a model of colitis. National Institutes of Health, National Institute of Allergy and Infectious Diseases, principal investigator ( 2.4 calendar months).

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 456-4343
Fax: (414) 266-6695
E-mail: cwilliam@mcw.edu

Investigator in the areas of:

• Cancer, immunology and host response