Calvin B. Williams, MD, PhD

Pediatric Rheumatology           

Title: Associate professor, Pediatrics (Microbiology and Molecular Genetics); section chief, Pediatric Rheumatology; D.B. and Marjorie Reinhart Chair in Pediatric Rheumatology.

Education: Medical degree, University of California, Irvine, 1991; doctorate, University of California, Irvine, 1991; residency, St. Louis Children's Hospital, 1993, fellowship, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, 1996.

Certifications: Pediatrics, Pediatric Rheumatology.

Honors: Summer fellowship, California Foundation for Biochemical Research, 1982; Earl C. Anthony Dissertation Fellowship, 1989; MRES Medical Scientist Student Scholarship, 1990; Vincent P. Carroll Jr., Memorial Research Award for Outstanding Research, 1992; Scholar of the Center for Child Health Research at Washington University, 1997; Basil O'Connor Research Award, March of Dimes, 1998; D.B. and Marjorie Reinhart Chair in Rheumatology, 2002; Elected member, Society for Pediatric Research, 2003; Outstanding Health Professional Award–Arthritis Foundation, Wisconsin Chapter, 2004.

Research interests: T cell development, regulatory T cell biology, tolerance, autoimmunity.

Representative publications:

• Haribhai D, Meyer MM, Engle DL, White JM, Williams CB. A Threshold for T cell Tolerance to an Inducible Serum Protein. Journal of Immunology 170:3007-14, 2003.
• Singh J, Williams CB, McAlister WH. Talo-patello-scaphoid Osteolysis, Synovitis and Short Fourth Metacarpals in Sisters: A New Syndrome? American Journal of Medical Genetics. 121A(2):118-125, 2003.
• Harbhai D, Edwards B, Williams ML, Williams CB. Functional Reprogramming of the Primary Immune Response by T Cell Receptor Antagonism. Journal of Experimental Medicine 200:1371-82, 2004.
• Lin D, Truong N, Grossman WJ, Haribhai D, Williams CB, Wang J, Martin MG, Chatila TA. Allergic Dysregulation and Hyperimmunoglobulinemia E in Foxp3 Mutant Mice. Journal of Allergy Clinical Immunology, 116:1106-15, 2005.
• Haribhai D., Lin W, Relland LM, Truong N, *Chatila TA, *Williams CB. Regulatory T cells Dynamically Control the Primary Immune Response to Foreign Antigen. Journal of Immunology 178:2961-72, 2007. *Denotes shared corresponding authorship.
• Lin W, Haribhai D, Relland LM, Truong N, Carlson MR, *Williams CB, *Chatila TA. Regulatory T cell Development in the Absence of a Functional Foxp3 Protein. National Immunology, 8:359-68, 2007. *Denotes shared corresponding authorship.

Current grants:

• Immune Function and Biodefense in Children, Elderly and Immunocompromised Populations, NIH NIAID. Co-investigator.
• The Role of Induced Regulatory T Cells in Dominant Immunological Tolerance, Advancing a Healthier Wisconsin. Principal investigator.

Contact information: 8701 Watertown Plank Road, Milwaukee, WI 53226. Phone: (414) 456-4343.  Fax: (414) 266-6695. E-mail: cwilliam@mcw.edu.