Fritz Sieber, PhD          

Titles
Investigator, Children's Research Institute; professor, Pediatrics and Medicine, Cell Biology, Neurobiology and Anatomy, Microbiology and Molecular Genetics, Medical College of Wisconsin.          

Division
Hematology, Oncology and Transplant

Research interests
Cancer

Study interests
Selenium-based experimental therapeutics, autologous hematopoietic stem cell transplantation, mitigation of radiation injury, photodynamic therapy.

Education
Doctorate, Swiss Federal Institute of Technology, Zurich, Switzerland, 1976; fellowship, The Johns Hopkins University, Baltimore, 1976-1979.     

Honors
Swiss National Science Foundation Fellow­, Swiss National Science Foundation Scholar, Hubert E. and Anne E. Rogers Award, Leukemia Society of America Scholar, Frederick Stohlman Memorial Award of the Leukemia Society of America, associate editor, Cancer Therapy and Control, editorial board/section editor, Cancer Research, Therapy & Control, editorial board, Current Chemical Biology.

Representative publications

• Miyagi K, Sampson RW, Sieber-Blum M, Sieber F. Crystal Violet and Merocyanine 540 for the ex vivo Purging of Hematopoietic Stem Cell Grafts. Photochemistry and Photobiology. 2003; 70:133-144.
• Sieber F, Daziano J-P, Gunther WHH, Krieg M, Miyagi K, Sampson RW, Ostrowski MD, Anderson GS, Tsujino I and Bula RJ. Elemental Selenium Generated by the Photobleaching of Selenomerocyanine Photosensitizers Forms Conjugates with Serum Macromolecules that are Toxic to Tumor Cells. Phosphorus Sulfur, and Silcon and the Related Elements. 2005; 180:647-657.
• Sieber F, Daziano J-P, Sampson RW, Tsujino I. Miyagi K, Ostrowski MD, Anderson GS, Gunther WHH and Krieg M. Role of Photoproducts in the Cytotoxic Action of Selenomerocyanine-mediated Photodynamic Therapy.  In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV. D Kessel, ed. Proceedings of SPIE Vol 5689. The International Society for Optical Engineering, Bellingham. 2005; pp 56-65.
• Tsujino I, Miyagi, Sampson RW and Sieber F. Potentiation of the Anti-tumor Effect of Merocyanine 540-mediated Photodynamic Therapy by Amifostine and Amphotericin B. Photochemistry and Photobiology. 2006; 82:458-465.
• Sieber F, Gunther WHH, Daziano J-P, Krieg-Kowald M, Bousbaa J, Bula RJ. Method of Making and the Use of Cytotoxic Agents Containing Elemental Selenium. US Patent Application Serial Number 7,205,002, issued April 17, 2007.
• Sieber F, Muir SA, Cohen EP, North PE, Fish BL, Irving AA, Mader M, Moulder JE. High-dose Selenium for the Mitigation of Radiation Injury: a Pilot Study in a Rat Model. Radiat Research. 2009; 171:368-373.

Grants

• High-Dose Selenium for Mitigation of Radiation Injury, NIH, Center for Medical Countermeasures Against Radiological Terrorism, principal investigator.
• Mitigation of Radiation Injury in Brain Tumor Patients, Clinical and Translational Science Institute of Southeast Wisconsin and Advancing a Healthier Wisconsin, principal investigator.
• Mitigation of Radiation Injury in Pediatric Brain Tumor Patients, CHW-Rebecca Slye Cancer Care Fund, principal investigator.
• Selenium for Mitigation of Late Effects in Pediatric Brain Tumor Patients, St. Baldrick's Foundation (www.StBaldricks.org), principal investigator.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 456-4155
Fax: (414) 456-6543
E-mail: sieber@mcw.edu