Fritz Sieber, PhD

Hematology-Oncology             

Title(s): Professor, Pediatrics and Medicine; Cell Biology, Neurobiology and Anatomy; Microbiology and Molecular Genetics, Medical College of Wisconsin.          

Education: Dr sc nat ETH (PhD), Swiss Federal Institute of Technology, Zurich, Switzerland, 1976; fellowship, The Johns Hopkins University, Baltimore, 1976-1979.     

Honors: Willy Beusch Prize, Swiss National Science Foundation Fellow­ship, Scholarship for Advanced Young Scientists from Swiss National Science Foundation, Hubert E. and Anne E. Rogers Award, Leukemia Society of America Scholar, Frederick Stohlman Memorial Award of the Leukemia Society of America.

Research interests: Experimental therapeutics, development of new anti-cancer agents, conjugates of elemental selenium with serum proteins as a novel class of anti-cancer agents, photochemotherapy and ex vivo purging of autologous hematopoietic stem cell grafts.

Representative publications:

• Indig GL, Anderson GS, Nichols MG, Barlett JA, Mellon WS, Sieber F. Effect of Molecular Structure on the Performance of Triarylmethane Dyes as Therapeutic Agents for Photochemical Purging of Autologous Bone Marrow Grafts from Residual Tumor Cells. Journal of Pharmaceutical Science 89:88-99, 2000.
• Tsujino I, Sieber F. Genetic Variability in the Response of Normal Murine Hematopoietic Progenitor Cells to Extracorporeal Photochemotherapy. Photochemistry and Photobiology 72:810-814, 2000.
• Tsujino I, Anderson GS, Sieber F. Post-irradiation Hyperthermia Selectively Potentiates the Merocyanine 540-sensitized Photoinactivation of Small Cell Lung Cancer Cells. Photochemistry and Photobiology 73:191-198, 2001.
• Anderson GS, Miyagi K, Sampson RW, Sieber F. Anti-tumor Effect of Merocyanine 540-mediated Photochemotherapy Combined with Edelfosine: Potential Implications for the ex vivo Purging of Hematopoietic Stem Cell Grafts from Breast Cancer Patients. Photochemistry and Photobiology 68:101-108, 2002.
• Anderson GS, Tsujino I, Miyagi K, Sampson RW, Sieber F. Preferential Inactivation of Paediatric Solid Tumour Cells by Sequential Exposure to Merocyanine 540-mediated Photodynamic Therapy and Edelfosine: Implications for the ex vivo Purging of Autologous Haematopoietic Stem Cell Grafts. Photochemistry and Photobiology 69:87-95, 2003.
• Miyagi K, Sampson RW, Sieber-Blum M, Sieber F. Crystal Violet and Merocyanine 540 for the ex vivo Purging of Hematopoietic Stem Cell Grafts. Photochemistry and Photobiology 70:133-144, 2003.

Current grants:

• Proteinated Subnano Particles of Elemental Selenium for the Treatment of Breast Cancer, Department of Defense Breast Cancer Research Program, BC031247, principal investigator.
• Merocyanine Photoproducts With Antineoplastic Activity National Institutes of Health, RO1-CA77387-04S1, principal investigator.
• Proteinated Subnanoparticles of Elemental Selenium as a New Class of Anti-Cancer Agents: Custom Synthesis of Pro-Drug and Testing in Hollow Fiber Assay. National Cancer Institute, Rapid Access to NCI Discovery Resources (RAND), principal investigator.
• Proteinated Subnano Particles of Elemental Selenium for the Treatment of Human Prostate Cancer in Mouse Xenograft Models, Medical College of Wisconsin Cancer Center, principal investigator.

Contact information: 8701 Watertown Plank Road, Milwaukee WI 53226. Phone: (414) 456-4155. Fax: (414) 456-6543. E-mail: sieber@mcw.edu.