Robert Montgomery, MD

Hematology                                                     

Title(s): Professor, Pediatrics (Hematology) and vice chair, Research, Medical College of Wisconsin; senior investigator, Blood Research Institute.

Education: Medical degree, University of Pittsburgh School of Medicine, Pittsburgh, Pa., 1969; internship, Children's Hospital of Philadelphia 1969-1970; residency, Johns Hopkins Hospital, Baltimore, 1972–1973; fellowships, Pediatric Hematology, University of Colorado, Denver, 1973–1976, and Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, Calif., 1976–1977.

Certifications: Pediatrics 1976; Pediatric Hematology 1976.

Honors: National Research Service Award, Heart, Lung and Blood Institute, National Institutes of Health, 1975‑1977; Young Investigator Award, Heart, Lung and Blood Institute, National Institutes of Health, 1978‑1981; Established Investigator Award, American Heart Association, 1982–1987; Jack Kennedy Alumni Achievement Award, Grove City College, Grove City, Pa., 1985; Walter A. Schroeder Chair of Blood Research, The Blood Center of Southeastern Wisconsin, 1986–1994; The Dr. Murray Thelin Award, National Hemophilia Foundation, 1991; ISTH Investigator Recognition Biennial Award, ISTH XVIIIth Congress, Paris, France, 2001.

Research interests: Von Willebrand disease, hemophilia, gene therapy, Bernard Soulier syndrome, platelet glycoprotein receptors, endothelial and platelet protein sorting.

Representative publications:

• Haberichter SL, Jozwiak MA, Rosenberg JB, Christopherson PA, Montgomery RR. The von Willebrand Factor Propeptide, VWFpp, Traffics An Unrelated Protein to Storage. Arteriosclerosis, Thrombosis and Vascular Biology, 22:921-926, 2002.
• Kenny D, Morateck PA, Montgomery RR. The Cysteine Knot of Platelet Glycoprotein Ibb (GPIbb) is Critical for the Interaction of GPIbb with GPIX. Blood, 99(12): 4428-4433, 2002.
• Rosenberg JB, Haberichter SL, Jozwiak MA, Vokac EA, Kroner PA, Fahs SA, Kawai Y, Montgomery RR. The Role of the D1 Domain of the von Willebrand Factor Propeptide in Multimerization of VWF. Blood, 100(5):1699-1706, 2002.
• Haberichter SL, Jacobi P, Montgomery RR. Critical Independent Regions in the VWF Propeptide and Mature VWF That Enable Normal VWF Storage. Blood 101(4):1384-1391, 2003.
• Shi Q, Wilcox DA, Fahs SA, Kroner PA, Montgomery RR. Expression of Human Factor VIII under Control of the áIIb Platelet-Specific Promoter in Megakaryocytic Cell Line as well as Storage Together with VWF. Molecular Genetics and Metabolism 79:25-33, 2003.
• Wilcox DA, Rosenberg JB, Shi Q, Johnson B, White GC II, Montgomery RR. Megakaryotcyte Synthesis of Recombinant Factor VIII Results in Platelet a-Granules Storage. Journal of Thrombosis and Haemostasis 1: 2477-2489, 2003.

 Current grants:

• Structure and Function of VWFpp, RO1 HL33721 – 16, 1999–2008, principal investigator.
• Program Project Molecular and Cellular Mechanisms in Transfusion Medicine, Project 5, Molecular and Cellular Consequences of VWF Alteration, PO1 HL44612 – 13, 2000–2005, principal investigator.

Contact information: Department of Pediatrics, PO Box 26509, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509. Phone: (414) 456-4311. Fax: (414) 456-6613. E-mail: bob@bcw.edu.