• Bryon D. Johnson, PhD

Bryon Johnson, PhDTitles
Investigator, Children's Research Institute; associate professor, Medical College of Wisconsin.

Division
Hematology, Oncology and Transplant

Research interests
Cancer

Study interests
Transplantation immunology, cancer immunotherapy, immune regulation, neuroblastoma, multiple myeloma, tumor vaccines, cellular therapies for cancer.

Education
Doctorate, University of Health Sciences/The Chicago Medical School (now Rosalind Franklin University),  North Chicago, 1989.

Honors
Best abstracts award at the American Society for Blood and Marrow Transplantation Annual Meeting, Miami, 1999; Ernest McCulloch and James Till Award for the best science article in Biology of Blood and Marrow Transplant by a new investigator at the ASBMT Annual Meeting, Anaheim, Calif., 2000; invited speaker at "Converging Therapies: The Role of Mixed Chimerism in Transplantation Tolerance and in the Treatment of Hematologic Malignancies" symposium, Boston, 2001; invited speaker at "Graft-versus-Host and Graft-versus-Leukemia Reactions 2002" international symposium, Munich, Germany, 2002; member, editorial board, Biology of Blood and Marrow Transplantation; ad hoc grant reviewer for the National Institutes of Health.

Representative publications

  • Jing W, Gershan J and Johnson BD. Depletion of CD4 T Cells Enhances Immunotherapy for Neuroblastoma after Syngeneic HSCT but Compromises Development of Anti-Tumor Immune Memory. Blood. 2009; 113:4449.
  • Cludts S, Decaestecker C, Johnson B, Lechien J, Leroy X, Kindt N, Kaltner H, Andre S, Gabius H-J and Saussez S. Increased Expression of Macrophage Migration Inhibitory Factor during the Progression Hypopharyngeal Squamous Cell Carcinoma. Anticancer Research. 2010; 30:3313.
  • Kohler ME, Johnson BD, Palen K, Chen Q-R, Khan J, and Orentas RJ. Tumore Antigen Analysis in Neuroblastoma by Serological Interrogation of Bioinformatic Data. Cancer Science. 2010; 101:2316.
  • Kohler ME, Hallett W.H.D., Chen Q-R, Khan J, Johnson BD and Orentas RJ. Early Expression of Stem Cell-Associated Genes within the CD8 Compartment after Treatment with a Tumor Vaccine. Cell. Immunol. 2010; 265:65.
  • Hallett W.H.D., Jing W, Drobyski WR and Johnson BD. Immunosuppressive Effects of Multiple Myeloma are Overcome by PD-L1 Blockade. Biol of Blood and Marrow Transpl. 2011; 17:1133.
  • Jing W, Yan X, Hallett W.H.D., Gershan JA and Johnson BD. Depletion of CD25' T Cells from Hematopoitic Stem Cell Grafts Increases Post-Transplant Vaccine-Induced Immunity to Neuroblastoma. Blood. 2011; 117:6952.

Grants

  • Optimizing Immunotherapy for Neuroblastoma after BMT, National Institutes of Health/National Cancer Institute, principal investigator, 2009-2014.
  • Translational Studies of Cell-based Vaccines for Childhood Cancer, The Midwest Athletes Against Childhood Cancer Fund, co-investigator, 2007-2012.
  • This is general research support awarded on an annual basis through MACC Fund contributions to the Midwest Children's Cancer Center, Midwest Athletes Against Childhood Cancer (MACC) Fund, principal investigator, 2011-2012.

Contact
Department of Pediatrics, Hematology-Oncology
Medical College of Wisconsin
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 955-4123
E-mail: bjohnson@mcw.edu 

Investigator in the areas of: