Bryon D. Johnson, PhD
Titles Investigator, Children's Research Institute; associate professor, Medical College of Wisconsin.
Division Hematology, Oncology and Transplant
Research interests Cancer, infectious/immunological diseases
Study interests Bone marrow transplantation, immune memory, immune therapy for cancer, pediatric malignancies, neuroblastoma, tumor vaccines.
Education Doctorate, University of Health Sciences/The Chicago Medical School, North Chicago, 1989.
Honors Best abstracts award at the American Society for Blood and Marrow Transplantation Annual Meeting, Miami, 1999; Ernest McCulloch and James Till Award for the best science article in Biology of Blood and Marrow Transplant by a new investigator at the ASBMT Annual Meeting, Anaheim, Calif., 2000; invited speaker at "Converging Therapies: The Role of Mixed Chimerism in Transplantation Tolerance and in the Treatment of Hematologic Malignancies" symposium, Boston, 2001; invited speaker at "Graft-versus-Host and Graft-versus-Leukemia Reactions 2002" international symposium, Munich, Germany, 2002; member, editorial board, Biology of Blood and Marrow Transplantation; ad hoc grant reviewer for the National Institutes of Health.
Representative publications
- Johnson BD, Jing W, Orentas RJ. CD25 Regulatory Cell Blockade Enhances Vaccine-Induced Immunity to Neuroblastoma. Journal of Immunotherapy. 2007; 30:203.
- Jing W, Orentas RJ, Johnson BD. Induction of Immunity to Neuroblastoma Early after Syngeneic Hematopoietic Stem Cell Transplantation Using a Novel Mouse Tumor Vaccine. Biology of Blood and Marrow Transplant. 2007; 13:277.
- Keever-Taylor CA, Browning MB, Johnson BD, Truitt RL, Bredeson CN, Behn B, Tsao A. Rapamycin Enriches for CD4+CD25+CD27+Foxp3+ Regulatory T Cells in Ex Vivo Expanded CD25-Enriched Products from Healthy Donors and Patients with Multiple Sclerosis. Cytotherapy. 2007; 9:144.
- Zheng J, Kohler ME, Chen Q, Weber J, Khan J, Johnson BD, Orentas RO. Serum from Mice Immunized in the Context of Treg Inhibition Identifies DEK as a Neuroblastoma Tumor Antigen. BMC Immunology. 2007; 8:4.
- Zhou Q, Johnson BD, Orentas RO. Cellular Immune Response to an Engineered Cell-based Tumor Vaccine at the Vaccination Site. Cellular Immunology. 2007; 245:91.
- Chen X, Vodanovic-Jankovic S, Johnson B, Keller M, Komorowski R, Drobyski WR. Absence of Regulatory T Cell Control of TH1 and TH17 Cells is Responsible for the Autoimmune-Mediated Pathology in Chronic Graft-Versus-Host Disease. Blood. 2007; 110:3804.
Grants
- Optimizing Immunotherapy for Neuroblastoma after bone marrow transplant, National Institutes of Healthy/National Cancer Institute, principal investigator, 2004-2009.
- Cell-based Vaccines for Breast Cancer in the FVB/N (MMTV NEU) Mouse Model, Wisconsin Breast Cancer Showhouse, co-investigator, 2008-2010.
- Translational Studies of Cell-based Vaccines for Childhood Cancer, The Midwest Athletes Against Childhood Cancer Fund, co-investigator, 2007-2010.
Contact Children's Research Institute 8701 Watertown Plank Road Wauwatosa, WI 53226 Phone: (414) 445-4123 Fax: (414) 456-6482 E-mail: bjohnson@mcw.edu

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