Bryon D. Johnson, PhD

Titles
Investigator, Children's Research Institute; associate professor, Medical College of Wisconsin.

Division
Hematology, Oncology and Transplant

Research interests
Cancer, infectious/immunological diseases

Study interests
Bone marrow transplantation, immune memory, immune therapy for cancer, pediatric malignancies, neuroblastoma, tumor vaccines.

Education
Doctorate, University of Health Sciences/The Chicago Medical School, North Chicago, 1989.

Honors
Best abstracts award at the American Society for Blood and Marrow Transplantation Annual Meeting, Miami, 1999; Ernest McCulloch and James Till Award for the best science article in Biology of Blood and Marrow Transplant by a new investigator at the ASBMT Annual Meeting, Anaheim, Calif., 2000; invited speaker at "Converging Therapies: The Role of Mixed Chimerism in Transplantation Tolerance and in the Treatment of Hematologic Malignancies" symposium, Boston, 2001; invited speaker at "Graft-versus-Host and Graft-versus-Leukemia Reactions 2002" international symposium, Munich, Germany, 2002; member, editorial board, Biology of Blood and Marrow Transplantation; ad hoc grant reviewer for the National Institutes of Health.

Representative publications

• Johnson BD, Jing W, Orentas RJ. CD25 Regulatory Cell Blockade Enhances Vaccine-Induced Immunity to Neuroblastoma. Journal of Immunotherapy. 2007; 30:203.
• Jing W, Orentas RJ, Johnson BD. Induction of Immunity to Neuroblastoma Early after Syngeneic Hematopoietic Stem Cell Transplantation Using a Novel Mouse Tumor Vaccine. Biology of Blood and Marrow Transplant. 2007; 13:277.
• Keever-Taylor CA, Browning MB, Johnson BD, Truitt RL, Bredeson CN, Behn B, Tsao A. Rapamycin Enriches for CD4+CD25+CD27+Foxp3+ Regulatory T Cells in Ex Vivo Expanded CD25-Enriched Products from Healthy Donors and Patients with Multiple Sclerosis. Cytotherapy. 2007; 9:144.
• Zheng J, Kohler ME, Chen Q, Weber J, Khan J, Johnson BD, Orentas RO. Serum from Mice Immunized in the Context of Treg Inhibition Identifies DEK as a Neuroblastoma Tumor Antigen. BMC Immunology. 2007; 8:4.
• Zhou Q, Johnson BD, Orentas RO. Cellular Immune Response to an Engineered Cell-based Tumor Vaccine at the Vaccination Site. Cellular Immunology. 2007; 245:91.
• Chen X, Vodanovic-Jankovic S, Johnson B, Keller M, Komorowski R, Drobyski WR. Absence of Regulatory T Cell Control of TH1 and TH17 Cells is Responsible for the Autoimmune-Mediated Pathology in Chronic Graft-Versus-Host Disease. Blood. 2007; 110:3804.

Grants

• Optimizing Immunotherapy for Neuroblastoma after bone marrow transplant, National Institutes of Healthy/National Cancer Institute, principal investigator, 2004-2009.
• Cell-based Vaccines for Breast Cancer in the FVB/N (MMTV NEU) Mouse Model, Wisconsin Breast Cancer Showhouse, co-investigator, 2008-2010.
• Translational Studies of Cell-based Vaccines for Childhood Cancer, The Midwest Athletes Against Childhood Cancer Fund, co-investigator, 2007-2010.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 445-4123
Fax: (414) 456-6482
E-mail: bjohnson@mcw.edu