Ronald N. Hines, PhD

Birth Defects Research Center and Clinical Pharmacology, Pharmacogenetics and Teratology   

Title(s): Professor and co-section chief, Medical College of Wisconsin.

Education: Master of Science, RPMI Division, State University New York, Buffalo, N.Y., 1976; Doctor of Philosophy, University of Texas Southwestern Medical School, Dallas, 1980; postdoctoral fellowship, University of Vermont, Burlington, Vt., 1983.

Honors: Visiting Professor Scholarship, Danish Cancer Society, Fibiger Cancer Research Institute, Copenhagen, Denmark, 1987; Wayne State University Board of Governors Distinguished Faculty Fellow Award, 1998; Zeneca Traveling Lectureship, 2001.

Research interests: Mechanisms regulating drug/toxicant metabolizing enzymes, ontogeny of drug/toxicant metabolizing enzymes and genetic variability in drug/toxicant metabolizing enzymes.

Representative publications:

• Koukouritaki SB, Simpson P, Yeung CK, Rettie AE, Hines RN. Human Hepatic Flavin-Containing Monooxygenase 1 (FMO1) and 3 (FMO3) Developmental Expression. Pediatric Research. 51:236-243, 2002.
• Hines RN, Hopp KA, Franco J, Saeian K, Begun FP. Alternative Processing of the Human FMO6 Gene Renders Transcripts Incapable of Encoding a Functional Flavin-Containing Monooxygenase. Molecular Pharmacology. 62:320-325, 2002.
• Carr BA, Wan J, Hines RN, Yost GS. Characterization of the Human Lung CYP2F1 Gene and Identification of a Novel Lung-Specific Binding Motif. Journal of Biological Chemistry. 278:15473-15483, 2003.
• Hines RN, Luo Z, Hopp KA, Cabacungan ET, Koukouritaki SB, McCarver DG. Genetic Variability at the Human FMO1 Locus: Significance of a Yin Yang 1 Element Polymorphism (FMO1*6). Journal of Pharmacology. Expt'l. Ther. 306:1210-1218, 2003.
• Stevens JC, Hines RN, Gu C, Koukouritaki SB, Manro JR, Tandler PJ, Zaya MJ. Developmental Expression of the Major Human Hepatic CYP3A Enzymes. Journal of Pharmacology. Expt'l. Ther.307:573-582, 2003.
• Koukouritaki SB, Manro JR, Marsh SA, Stevens JC, Rettie AE, McCarver DG, Hines RN. Developmental Expression of Human Hepatic CYP2C9 and CYP2C19. Journal of Pharmacology. Expt'l. Ther.308:965-974, 2004.

Current grants:

• Regulation of Flavin-Monooxygenase Gene Expression, NIH, NCI, PI.
• Pharmacogenetics of ADRs: Warfarin Toxicity, NIH, NIGMS, Co-PI.

Contact information: Clinical Pharmacology, Pharmacogenetics and Teratology, 8701 Watertown Plank Road, Wauwatosa, WI 53226-4801. Phone: (414) 456-4322. Fax: (414) 456-6651. E-mail: rhines@mcw.edu