Martin J. Hessner, PhD

Titles
Director, Max McGee National Research Center for Juvenile Diabetes, Children's Research Institute; professor, Pediatrics, Medical College of Wisconsin.

Division
Endocrinology/Diabetes

Research center/program
Max McGee National Research Center for Juvenile Diabetes

Research interests
Diabetes

Study interests
Autoimmunity, Type 1 Diabetes, Functional Genomics.

Education
Doctorate, Microbiology/Molecular Biology, University of Wisconsin-Milwaukee, 1990; fellowship, Product Development Associate, DNA/Cancer Diagnostics Laboratories, BloodCenter of Wisconsin, Milwaukee, 1993.

Honors
Invited Speaker, Ninth Annual Rachmiel Levine Diabetes and Obesity Symposium, 2009; Invited Speaker, Tenth International Congress of the Immunology of Diabetes Society, 2009; Invited Speaker, American Diabetes Association's 70th Annual Meeting, 2010.

Representative publications

• Hessner MJ, Wang X, Meyer L, Geoffrey R, Jia S, Fuller J, Lernmark A, Ghosh S. Involvement of Eotaxin, Eosinophilis and Pancreatic Predisposition in Development of Type 1 Diabetes in the BioBreeding Rat. Journal of Immunology. 2004; 173:6993. PMID: 15557196.
• Geoffrey R, Jia S, Kwitek AE, Ghosh S, Lernmark A, Wang X, Hessner MJ. Evidence of a Functional Role for Mast Cells in the Development of Type 1 Diabetes Mellitus in the BioBreeding Rat. Journal of Immunology. 2006; 177:7275. PMID: 17082646. 
• Wang X, Jia S, Geoffrey R, Alemzadeh R, Ghosh S, Hessner MJ. Identification of a Molecular Signature in Human Type 1 Diabetes Mellitus using Serum and Functional Genomics. Journal of Immunology. 2008; 180(3):1929-1937. PMID: 18209091.
• Kaldunski M, Jia S, Geoffrey R, Basken J, Prosser S, Kansra S, Mordes JP, Lernmark A, Wang X, Hessner MJ. Identification of a Serum Induced Transcriptional Signature Associated with Type 1 Diabetes in the BioBreeding Rat. Diabetes. 2010; 59(10):2375-2385. PMID: 20682698.
• Jia S, Kaldunski ML, Jailwala P, Geoffrey R, Kramer J, Wang X, Hessner MJ. Use of Transcriptional Signatures Induced in Lymphoid and Myeloid Cell Lines as an Inflammatory Biomarker in Type 1 Diabetes. Physiol Genomics. 2011; 43(11):697-709. PMID: 21406607.
• Haribhai D, Williams JB, Jia S, Nickerson D, Schmitt EG, Edwards B, Ziegelbauer J, Yassai M, Li SH, Relland LM, Wise PM, Chen A, Zheng YQ, Simpson PM, Gorski J, Salzman NH, Hessner MJ, Chatila TA, Williams CB. A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity. Immunity. 35(1):109-22. PMID: 21723159.

Grants

• Dissection of Cellular Interactions in T1DM with Integrated Functional Genomics (RO1 AI078713-07), National Institutes of Health, National Institute of Allergy and Infectious Diseases, principal investigator.
• Serum Induced Transcriptional Signatures in T1DM, Juvenile Diabetes Research Foundation International, principal investigator.
• Optimizing Immunotherapy for Neuroblastoma after BMT (R01 CA100030-08), National Institutes of Health, National Cancer Institute, co-investigator.
• Anesthetics and Cardiac Signal Transduction (2R01 HL034708-23), National Institutes of Health, National Heart,  Lung, and Blood Institute, co-investigator.
• Integration of Genomics with Genetics-Molecular Phenotypes in CF Lung Disease (IDP2OD007031-01), National Institutes of Health, National Heart, Lung, and Blood Institute, co-investigator.
• Integrative Genomics to Dissect the Genetic Regulation of T1D Onset, (R01 DK080100-03), co-investigator.
• Genetic Dissection of BB Rat Autoimmunity, (1P01-A142380-09, project co-leader.
• The role of IL-1 in Type 1 Diabetes, Advancing a Healthier Wisconsin Initiative #5520065, principal investigator.

Contact
The Medical College of Wisconsin
Department of Pediatrics
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 456-4496
Fax: (414) 456-6663
E-mail: mhessner@mcw.edu