Martin J. Hessner, PhD

Titles
Director, Max McGee National Research Center for Juvenile Diabetes, Children's Research Institute; associate professor, Pediatrics, Medical College of Wisconsin.

Division
Endocrinology/Diabetes

Research center/program
Cardiothoracic Surgery, Max McGee National Research Center for Juvenile Diabetes

Research interests
Diabetes/obesity, genetic diseases/genomics

Study interests
Genetics of complex diseases, molecular diagnostics, type 1 diabetes.

Education
Doctorate, Microbiology/Molecular Biology, University of Wisconsin-Milwaukee, 1985-1990; fellowship, Product Development Associate, DNA/Cancer Diagnostics Laboratories, BloodCenter of Wisconsin, Milwaukee, 1991-1993.

Representative publications

• Hessner MJ, Wang X, Meyer L, Geoffrey R, Jia S, Fuller J,  Lernmark A, Ghosh S. Involvement of Eotaxin, Eosinophilis and Pancreatic Predisposition in Development of Type 1 Diabetes Mellitus in the BioBreeding Rat. The Journal of Immunology. 2004; 173 (11):6993-7002.
• Wang X, Jia S, Meyer L, Xiang B, Chen LY, Jiang N, Moreno C, Jacob HJ, Ghosh S, Hesser MJ. Comprehensive Quality Control Utilizing the Prehybridization Third-dye Image Leads to Accurate Gene Expression Measurements by cDNA microarrays. BMC Bioinformatics. 2006; 7:378.
• Geoffrey R, Jia S, Kwitek AE, Ghosh S, Lernmark A, Wang X, Hessner MJ. Evidence of a Functional Role for Mast Cells in the Development of Type 1 Diabetes Mellitus in the BioBreeding Rat. The Journal of Immunology. 2006; 177:7275-86.
• Wang X, Jia S, Meyer L, Yassai M, Naumov YN, Gorski J, Hessner MJ. Quantitative Measurement of Pathogen Specific Human Memory T-cell Repertoire Diversity Using a CDR3-specific Mircoarray. BMC Genomics. 2006; 8(1):329.
• Wang X, Jia S, Geoffrey R, Alemzadeh R, Ghosh S, Hessner MJ. Identification of a Molecular Signature in Human Type 1 Diabetes Mellitus using Serum and Functional Genomics. Journal of Immunology. 2008; 180:1929-37.

Grants

• Serum Induced Transcriptional Signatures in TIDM, Juvenile Diabetes Research Foundation International, principal investigator.
• Dissection of Cellular Interactions with Integrated Functional Genomics in Complex Disease, NIH-NIAID, principal investigator.
• The Role of IL-1 Diabetes, Advancing a Healthier Wisconsin Program, principal investigator (5% effort).
• Integrative Genomics to Dissect the Genetic Regulation of TID, NIH-NIDDK, co-investigator.
• Genetic Dissection of BB Rat Autoimmunity, NIH-NIAID, co-investigator.
• Dissecting the Genetics of the Metabolis Syndrome on Chromosome 17 of the LH Rat, NIH-NHLB1, co-investigator.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 456-4496
Fax: (414) 456-6663
E-mail: mhessner@mcw.edu