Martin J. Hessner, PhD

Titles
Investigator, Children's Research Institute; associate professor, Pediatrics, Medical College of Wisconsin.

Division
Endocrinology/Diabetes

Research center/program
Max McGee National Research Center for Juvenile Diabetes

Research interests
Genetics of complex diseases, molecular diagnostics, type 1 diabetes.

Education
Doctorate, Microbiology/Molecular Biology, University of Wisconsin-Milwaukee, 1985-1990; fellowship, Product Development Associate, DNA/Cancer Diagnostics Laboratories, BloodCenter of Wisconsin, Milwaukee, 1991-1993.

Representative publications

• Hessner MJ, Wang X, Hulse K, Meyer L, Wu Y, Nye S, Guo SW, Ghosh S. Three Color cDNA Microarrays: Quantitative Assessment Through the Use of Fluorescein-labeled Probes. Nucleic Acids Research. 2003; 31:e14.
• Hessner MJ, Wang X, Khan S, Meyer L, Schlicht M, Tackes J, Datta MW, Jacob JH, Ghosh S. Use of a Three-color cDNA Microarray Platform to Measure and Control Support-bound Probe for Improved DAta Quality and Reproducibility. Nucleic Acids Research. 2003; 31:e60.
• Wang X, Jiang N, Feng X, Xie Y, Tonellato P, Ghosh S, Hessner MJ. A Novel Approach for Microarray Image Processing Using Third-dye Array Visualization Technology. IEEE Transactions on Nanobioscience. 2003; 2:103-201.
• Hessner MJ, Singh VK, Wang X, Khan S, Tschannen MR, Zahrt TC. Utilization of a Labeled Tracking Oligonucleotide for Visualization and Quality Control of Spotted 70-mer Arrrays. Genomics. 2004; 5:12.
• Hessner MJ, Wang X, Meyer L, Geoffrey R, Jia S, Fuller J, Lernmark A, Ghosh S. Involvement of Eotaxin, Eosinophils and Pancreatic Predisposition in Development of Type 1 Diabetes Mellitus in the BioBreeding Rat. The Journal of Immunology. 2004; 173(11):6993-7002.
• Hessner MJ, Xiang B, Jia S, Geoffrey R, Holmes S, Myer L, Muheisen S, Wang X. Three-color cDNA Microarrays with Prehybridization Quality Control Yield Gene Expresion Data Comparable to that of Commercial Platforms. Physiological Genomics. 2006; 25:166-78.
• Hessner MJ, Liang M, Kwitek AE. The Application of Microarray Analysis to Pediatric Diseases. Pediatric Clinics of North America. 2006; 53:579-590.
• Wang X, Jia S, Meyer L, Xiang B, Chen LY, Jiang N, Moreno C, Jacob JH, Ghosh S, Hessner MJ. Comprehensive Quality Control Utilizing the Prehybridization Third-dye Image Leads to Accurate Gene Expression Measurements by cDNA Microarrays. BMC Bioinformatics. 2006; 7:378.
• Geoffrey R, Jia S, Kwitek AE, Ghosh S, Lernmark A, Wang X, Hessner MJ. Evidence of a Functional Role for Mast Cells in the Development of Type 1 Diabetes Mellitus in the BioBreeding Rat. The Journal of Immunology. 2006; 177:7275-86.
• Wang X, Jia S, Meyer L, Yassai M, Naumov YN, Gorski J, Hessner MJ. Quantitative Measurement of Pathogen Specific Human Memory T-cell Repertoire Diversity Using a CDR3a-specific Mircoarray. BMC Genomics. 2007; 8(1):329.

Grants

• High-density Microarrays with Quantitative QC/Q, principal investigator, National Institutes of Health, 1 RO1 EB001421-01, NIH-National Institute of Biomedical Imaging and BioEngineering, 2003-2007.
• Construction and Validation of F. tularensis Oligoarray, co-investigator, NIIH-National Institute of Allergy and Infectious Disease, 2004-2006.

Contact
Children's Research Institute
8701 Watertown Plank Road
Wauwatosa, WI 53226
Phone: (414) 456-4496
Fax: (414) 456-6663
E-mail: mhessner@mcw.edu