James Tweddell, MD

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Specialty(ies)

• Cardiothoracic Surgery
• Cardiothoracic Surgery, Pediatric

Board Certification(s)

• Thoracic Surgery
• Surgery

Education

• MD: University of Cincinnati, 1981 - 1985.
• Internship: New York University, NY (General Surgery) 1985 - 1986.
• Residency: New York University, NY (General Surgery) 1986 - 1987.
• Residency: Washington University, St. Louis, MO (General Surgery) 1987 - 1991.
• Fellowship: Washington University, St. Louis, MO (Thoracic-Cardiovascular Surgery) 1991 - 1993.
• Fellowship: Washington University, St. Louis, MO (Pediatric Thoracic-Cardiovascular Surgery) 1991 - 1993.

Employment

• 1993: Instructor in Surgery, Division of Cardiothoracic Surgery, Washington University, St. Louis, MO.
• 1994 - 1998: Assistant professor of Surgery and Pediatrics, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee.
• 1994 - 1996: Director of Heart Transplantation, Division of Cardiothoracic Surgery, Medical College of Wisconsin and John L. Doyne Hospital, Milwaukee.
• 1995 - present: Director of Cardiothoracic Transplantation, Children's Hospital of Wisconsin, Milwaukee.
• 1996 - 2000: Director of Heart Transplantation, Division of Cardiothoracic Surgery, Medical College of Wisconsin and Froedtert Memorial Lutheran Hospital, Milwaukee.
• 1998 - present: Associate professor of Surgery (Cardiothoracic) and Pediatrics, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee.
• 2001 - present: Chief, Cardiothoracic Surgery, Children's Hospital of Wisconsin, Milwaukee. 
• 2001 - present: S. Bert Litwin Chair in Cardiothoracic Surgery, Children's Hospital of Wisconsin, Milwaukee.
• 2001 - present: Director of Pediatric Cardiothoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee.
• Dec 1, 2002: Interim chief, Cardiothoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee.
• 2002: Director, Cardiothoracic Surgery Residency Program, Medical College of Wisconsin, Milwaukee.
• 2003: Professor of Surgery (Cardiothoracic) and Pediatrics, Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee.
• July 2004: Chief, Cardiothoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, Medical College of Wisconsin.

Publications

1. Tweddell JS, Waymack JP, Warden GD, Law EJ, Jenkins M, Alexander JW: Hematuria in the burned child. Journal of Pediatric Surgery, 22(10):899-903, 1987.
2. Tweddell JS, Harada A, Schuessler RB, Stone CM, Rokkas CK, Branham BH, Boineau JP, Cox JL: Computerized potential distribution mapping for the rapid localization of ventricular tachycardia of septal origin. Surgical Forum 39:257-259, 1988.
3. Tweddell JS, Branham BH, Harada A, Stone CM, Rokkas CK, Schuessler RB, Boineau JP, Cox JL: Potential mapping in septal tachycardia: Evaluation of a new intraoperative mapping technique. Circ 80 Suppl. I):I-97--I-108. 1989.
4. Tweddell JS, Branham BH, Stone CM, Schuessler RB, Boineau JP, Cox JL: Focal cryoablation guided solely by intraoperative potential distribution mapping ablates ventricular tachycardia of endocardial origin. Surgical Forum 40:216-218, 1989.
5. Tweddell JS, Branham BH, Rokkas CK, Pirolo JS, Schuessler RB, Boineau JP, Cox JL: Anterior septal coronary occlusion in the canine: A model of ventricular tachycardia with a subendocardial origin. Surgical Forum 42:255-257, 1991.
6. Tweddell JS, Canter CE, Bridges ND, Moorhead S, Huddleston CB, Spray TL: Predictors of operative mortality and morbidity after infant heart transplantation. Ann Thorac Surg 58:972-977, 1994.
7. Tweddell JS, Rokkas CK, Harada A, Pirolo JS, Branham BH, Schuessler RB, Boineau JP, Cox JL: Anterior septal coronary infarction in the canine: A model of ventricular tachycardia with a subendocardial origin. Ablation and activation sequence mapping. Circ 90:2982-2992, 1994.
8. Tweddell JS, Zimmerman ANE, Stone CM, Rokkas CK, Schuessler RB, Boineau JP, Cox JL: Pericardiocentesis guided by a pulse generator. J Am Coll Cardiol 14:1074-1083, 1989.
9. Tweddell JS, Litwin SB, Berger S, Friedberg DZ, Thomas JP, Gallen WJ, Frommelt PC, Frommelt MA, Pelech AN, Lewis DA, Fedderly RT, Mussatto KA, Kessel MA. Twenty year experience with repair of complete atrioventricular septal defects. Ann Thorac Surg 62:419-24,1996.
10. Tweddell JS, Berger S, Frommelt PC, Pelech AN, Lewis DA, Fedderly RT, Frommelt MA, McManus T, Mussatto KA, Kessel MA, Litwin SB. Aprotinin improves outcome of single ventricle palliation. Ann Thorac Surg 1996;62:1329-36.
11. Tweddell JS, Hoffman GM, Fedderly RT, Berger S, Thomas JP, Ghanayem N, Kessel MA, Litwin SB. Phenoxybenzamine improves systemic oxygen delivery after the Norwood procedure. Ann Thorac Surg 67:161-168, 1999.
12. Tweddell JS, Litwin SB, Thomas JP, Mussatto KA. Recent advances in the surgical management of the single ventricle patient. Pediatric Clinics of North America. April 1999, 46(2):465-480.
13. Tweddell JS, Pelech AN, Frommelt PC, Wyman JD, Mussatto KA, Fedderly RT, Berger S, Frommelt MA, Lewis DA, Friedberg DZ, Thomas JP, Litwin SB. Factors affecting the longevity of homograft valves utilized in RVOT reconstruction for congenital heart disease. Circulation 2000;102 (Suppl III):130-35.
14. Tweddell JS, Hoffman GM, Fedderly RT, Ghanayem NS, Kampine, JM, Berger S, Mussatto, KA, Litwin, SB. Patients at risk for low systemic oxygen delivery after the Norwood procedure. Ann Thorac Surg 2000;69:1898-9.
15. Hoffman, GM, Ghanayem NS, Kampine JM, Berger S, Mussatto KA, Litwin SB, Tweddell JS. Venous Saturation and the Anaerobic Threshold in Neonates After the Norwood Procedure for Hypoplastic Left Heart Syndrome. Ann Thorac Surg 2000;70;1515-21.
16. Tweddell JS, Litwin SB. Transposition of the Great Arteries. Operative Techniques in Thoracic and Cardiovascular Surgery: A Comparative Atlas. Feb 2002 Vol 7, No 1.
17. Jaquiss RDB, Ghanayem NS, Zacharisen MZ, Mussatto KM, Tweddell JS, Litwin SB Safety of aprotinin use and re-use in pediatric cardiothoracic surgery Circulation 2002;106.
18. Tweddell JS, Hoffman GM, Mussattoo KA, Fedderly RT, Berger S, Jaquiss RDB, Ghanayem NS, Frisbee SJ, Litwin SB. Improved Survival of Patients Undergoing Palliation of Hypoplastic Left Heart Syndrome: Lessons Learned from 115 Consecutive Patients. Circulation 2002:106.
19. Ghanayem NS, Hoffman GM, Mussatto KA, Cava JR, Frommelt PC, Rudd NA, Steltzer MM, Bevandic SM, Frisbee SJ, Jaquiss RDB, Litwin SB, Tweddell JS. Home surveillance program prevents interstage mortality following the Norwood procedure. J Thorac Cardiovasc Surg,126(5), 1367-1377, Nov 2003.
20. Stuth EAE, Stucke AG, Fedderly RT, Tweddell JS. Complete Staged palliation of hypoplastic left heart syndrome in a child with cystic fibrosis. Paediatric Anaesthesia, 13(4) 345-348, May 2003.
21. Tweddell JS, Pelech AN, Frommelt PC, Jaquiss RDB, Hoffman GM, Mussatto KA, Litwin SB. Complex aortic valve repair provides a durable and effective alternative to valve replacement in children with aortic valve disease. J Thorac Cardiovasc Surg, (In press) 2004.

Research

1. Principal investigator: James S. Tweddell, MD, Pediatric Development, Medical College of Wisconsin, 06/16/99 to 06/30/08, $ 22,845.
2. Principal investigator: James S. Tweddell, M.D. Seprafilm II Adhesion Barrier in Pediatric Cardiac Surgery, Genzyme Corporation, Cambridge, MA, 09/01/99 to 08/31/00, $7,000.
3. Principal investigator: James S. Tweddell, MD, Nitric Oxide and Tolerance of Hyposix Heart to Ischemia, Children's Hospital Foundation, 07/01/00 to 06/30/01, $50,000.
4. Principal investigator: James S. Tweddell, MD, co-Investigators: S. Bert Litwin, MD, Andrew Pelech, MD, Ekehard Stuth, MD, $13,070, Pharmacokinetics of Brevibloc for Treatment of Hypertension, Baxter Pharmaceutical Products Inc, New Providence, NJ, 09/15/00-09/14/01.