MILWAUKEE (5/2/2013) - The Medical College of Wisconsin and Children's Hospital of Wisconsin Research Institute received a three-year, $857,000 grant from the National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases to continue to develop an assay shown to detect inflammation linked to the development of Type 1 diabetes (T1D) before patients are symptomatic.
Martin J. Hessner, Ph.D., professor of pediatrics, investigator at the Children's Hospital of Wisconsin Research Institute, and director of the Max McGee National Research Center for Juvenile Diabetes at Children's Hospital, is the primary investigator. Carla J. Greenbaum, M.D., director of the diabetes research program at the Benaroya Research Institute at Virginia Mason Medical Center in Seattle, is co-primary investigator.
Many inflammatory diseases, including T1D, become evident only after tissue damage has progressed and patients show signs of illness.
The researchers have developed a bioassay that measures a T1D signature that indicates early signs of inflammation. In all cases studied in which patients developed T1D, the signature was evident prior to disease onset. In this study, the research team aims to define that signature as a quantitative early biomarker to stage the disease, and also to define disease-specificity of the signature for T1D.
This project could potentially lead to new technological developments that would help predict T1D in patients before the onset of symptoms, which would allow for earlier intervention and preservation of pancreatic function.
About the Medical College of Wisconsin
The Medical College of Wisconsin is the state's only private medical school and health sciences graduate school. Founded in 1893, it is dedicated to leadership and excellence in education, patient care, research and service. More than 1,200 students are enrolled in the Medical College's medical school and graduate school programs. A major national research center, it is the largest research institution in the Milwaukee metro area and second largest in Wisconsin. In FY 2011 – 12, faculty received more than $166 million in external support for research, teaching, training and related purposes, of which more than $152 million is for research. This total includes highly competitive research and training awards from the National Institutes of Health (NIH). Annually, College faculty direct or collaborate on more than 2,000 research studies, including clinical trials. Additionally, more than 1,350 physicians provide care in virtually every specialty of medicine for more than 425,000 patients annually.
About Children's Hospital of Wisconsin
Children's Hospital of Wisconsin is the region's only independent health care system dedicated solely to the health and well-being of children. The hospital, with locations in Milwaukee and Neenah, Wis., is recognized as one of the leading pediatric health care centers in the United States and is ranked No. 4 in the nation by Parents magazine. Children's Hospital provides primary care, specialty care, urgent care, emergency care, community health services, foster and adoption services, child and family counseling, child advocacy services and family resource centers. In 2011, Children's Hospital invested more than $100 million in the community to improve the health status of children through medical care, advocacy, education and pediatric medical research. Children's Hospital achieves its mission in part through donations from individuals, corporations and foundations and is proud to be a member of Children's Miracle Network Hospitals. For more information, visit the website at chw.org.